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The psilocybin trial looked interesting, but the placebo group received niacin: "More participants receiving psilocybin had sustained response (but not remission) than those receiving niacin. There were no serious treatment-emergent AEs; however, psilocybin treatment was associated with a higher rate of overall AEs and a higher rate of severe AEs."

Looking forward to reading the paper on the inverse vaccine design too!

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I am not familiar with Niacin. It was described as an 'active placebo', I guess to make the effect more tangible for the control group? What do you think the implications of its use are for the control group?

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My thinking is that niacin could modulate the tryptophan-kynurenine pathway and provide some beneficial mental health effects via that mechanism.

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So sad to hear Ming was killed to determine their actual age, learning that it was 100 years older than expected! 🤯

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